Ion mobility spectrometry crc press book since the turn of the twentyfirst century, applications of ion mobility spectrometry ims have diversified, expanding their utility in the military and security spheres and entering the realms of clinical practice and pharmaceutical exploration. Advancements of mass spectrometry in biomedical research. Fundamentals of mass spectrometry ion mobility spectrometry toshiki sj department of chemistry, toho university, funabashi, chiba, japan ion mobility spectrometry ims has the same long history as mass spectrometry ms. Ion mobilitymass spectrometry methods and protocols. Ion mobilitymass spectrometry wentao jiang and rena a. Ionmobility spectrometrymass spectrometry, also known as ionmobility separationmass spectrometry, is an analytical chemistry method that separates gas phase ions based on their interaction with a collision gas and their masses. Theory and applications covers the tools, techniques, and applications involved when molecular size and shape information is. Pdf recent developments in ion mobility spectrometry.
Introduction this book focuses on ion mobilitymass spectrometry imms and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of stateoftheart imms technology for the most common analytical applications. The mobility of ions is based on their size, shape, and charge, thus ims provides insights into structure. Field asymmetric ion mobility spectrometry faims is a variant of ion mobility spectrometry a method of distinguishing charged gaseous molecules according to differences in the speed that they move through a buffer gas under the influence of an oscillating electric field. Advances in ion mobility spectrometrymass spectrometry. While implementation of im with ms usually requires complex instrumentation with delicate controls, in this study we explored the potential of performing im separation using duallinear ion traps lits in a miniature mass spectrometer, which was originally developed.
In this work, we coupled ion mobility spectrometry with mass spectrometry imsms to characterize glycan standards and biologically important isomers of synthetic. Ion mobility spectrometry ims is an atmospheric pressure technique for trace analysis of gasphase analytes. Fundamentals, instrumentation and applications, volume 83 1st edition. The analytical power of ion mobility spectrometrymass spectrometry. Ion mobility mass spectrometry jump to main content. Mass analysis of mobility selected io n populations using dual gate, ion mobility, quadrupole ion trap mass spectrometry. Purchase advances in ion mobility mass spectrometry. Sarah trimpin is an assistant professor at wayne state university in detroit, michigan. Synopsis this book focuses on ion mobilitymass spectrometry imms and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of stateoftheart imms technology for the most common analytical applications. Updated and expanded, the third edition of ion mobil. Offering a brief history of ion mobility spectrometry, this book explores its basic principles, discusses how it is applied, and projects future developments in the field.
Exploring these developments at this critical juncture, ion mobility spectrometrymass spectrometry. The analytical power of ion mobility spectrometrymass spectrometry imsms. Fundamentals of mass spectrometry ion mobility spectrometry. Ion mobility mass spectrometry the next 5 years, 2nd. Ion mobility spectrometry is a gasphase separation method that is applicable for a wide variety of substances.
The book accomplishes the objectives outlined by the authors the cd is a useful and practical addition to this book overall, this book should be useful to experts in ims research as well as those new to the technology. Recently, field asymmetric waveform ims faims has been gaining acceptance in similar applications. Ion mobility mass spectrometry the next 5 years, 2nd edition. Furthermore, new developments in hyphenated techniques, especially ion mobilitymass spectrometry couplings, resulted in an increased. Ion mobility spectrometry, volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of imms.
As such there is not a large software offering to display and analyze ion mobility mass spectrometric data, apart from the software packages that are shipped along with the instruments. Ion mobility maldi mass spectrometry and its applications two scientific developments that occurred in the early 1990s brought to the fore a new approach to solving biomolecular structures and enabled scientists in a wide variety of fields to make great strides in. Ion mobility spectrometry mass spectrometry theory and. Select series cyclic ims ion mobility mass spectrometer. Ion mobility spectrometry im has become an important analytical tool over the past 25 years. International journal for ion mobility spectrometry home. Ion mobility mass spectrometry analyst rsc publishing. Ion mobility separation using a duallit miniature mass. Ion mobility spectrometry ims separates ions based on their mobility in an inert buffer gas in the presence of an electric field. University of pittsburgh, pittsburgh, pa, usa 1 introduction 1 2 principles of ion mobility spectrometry 2. This book focuses on ion mobility mass spectrometry and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of stateoftheart imms technology for the most common analytical applications. Trimpin has received the american society for mass spectrometry research award, the dupont company young investigator award, and the german society for mass spectrometry wolfgangpaulstudienpreis and wolfgangpaulpromotionspreis. Ion mobilitymass spectrometry methods and protocols giuseppe. Ion mobility mass spectrometry is a rather recently popularized gas phase ion analysis technique.
Part c, es and maldi coupling to mass spectrometry instrumentation, examines the coupling of these ionization techniques to various mass analyzers, including quadrupole ion trap, timeofflight, fourier transform ion cyclotron resonance, and ion mobility mass spectrometers. The potential for ion mobility in pharmaceutical and. Book chapter full text access chapter three ion mobility mass spectrometry for chiral analysis of small molecules j. Ion mobility separation using a duallit miniature mass spectrometer. In the first step, the ions are separated according to their mobility through a buffer gas on a millisecond timescale using an ion mobility spectrometer. Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes argyris politis, 1 ah young park, 1 sukjoon hyung, 2 daniel barsky, 3 brandon t.
International journal of mass spectrometry elsevier. Ion mobility spectrometry ims has been explored for decades, and its versatility in separation and identification of gasphase ions, including in isomeric mixtures, is well established. Lipidomics is a rapidly growing field that enables the characterization of the entire lipidome in cells, tissues, or an organism. Ion mobility maldi mass spectrometry and its applications. Ion mobility spectrometry ims and mass spectrometry. Covers the end results of measurement, the mobility spectrum, and the transformative trend of ion mobility. The mobility of an ion is a measure of how rapidly an ion moves through a buffer drift gas under the influence of an electric field. Advancements of mass spectrometry in biomedical research pp 299316 cite as. Ion mobility mass spectrometry imms has been broadly utilized in the structural characterization of noncovalent, supramolecular complexes. Integrating ion mobility mass spectrometry with molecular. Galcontaining oglycans including glycotopes of the protozoan parasite trypanosoma cruzi, which is. The journal invites papers that advance the field of mass spectrometry by exploring fundamental aspects of ion processes using both the experimental and theoretical approaches, developing new instrumentation and experimental strategies for chemical analysis using mass spectrometry, developing new computational strategies for data interpretation. Separation and identification of isomeric species is a major challenge in lipidomics.
Ims separates ions in an electric field in the presence of an inert gas on the basis of their mobilities, a measure of the size tocharge ratio of an ion. Welcome to this analyst themed issue on ion mobility mass spectrometry, guest edited by perdita barran and brandon ruotolo. Offering a brief history of ion mobility spectrometry, this book explores its basic principles, discusses how it is currently applied, and projects future developments in the field. Ion mobility spectrometry, third edition serves specialists in the field of ims who are interested in the potential of recent developments and researchers, engineers, and students who want a comprehensive overview of this technology. Ion mobility spectrometry mass spectrometry by charles l. Ion mobilitymass spectrometry university of pittsburgh. Mclean and others published ion mobilitymass spectrometry find, read and cite all the research you need on researchgate. The tims analyzer is a segmented rf ion guide wherein ions are mobility analyzed using an electric field that holds ions stationary against a moving gas, unlike conventional drift tube ion mobility spectrometry. Interfacing ion mobility spectrometry to mass spectrometry imsms has enabled mass spectrometric analyses to extend into an extra dimension, providing unrivalled separation and structural characterization of lowly populated species in heterogeneous mixtures. In this chapter, we discuss three types of supramolecular complexes, and their structural dynamics observed in imms studies. Known also as plasma chromatography and ion chromatography, it has mainly been applied to the analysis of volatile organic compounds1, and used as a tool to probe the electronic states of ions.
Theory and applications covers the tools, techniques, and applications involved when molecular size and shape information is combined with the wellknown analytical advantages of highperformance mass spectrometry. Electrospray and maldi mass spectrometry wiley online books. The journal is the official publication of the international society of ion mobility spectrometry isims. In ims, the force exerted by an electric field on an analyte ion is exactly balanced by friction. This book focuses on ion mobility mass spectrometry imms and informatics approaches to improve traditional analysis of molecules by providing fundamentals and protocols for exploiting the potential of stateoftheart imms technology for the most common analytical applications. Chapters includes section on recent advances in imms, imms principles and theory, imms applications and instrumentation, and the future of imms. Other readers will always be interested in your opinion of the books youve read. Ionmobility spectrometrymass spectrometry wikipedia. The potential for ion mobility in pharmaceutical and clinical analyses. Herein, we demonstrate that lipid isomers that differ only in position of the acyl chain, position of the double bond or double bond geometry can be distinguished using drifttube ion mobilitymass spectrometry, even in complex biological samples. Borrow ebooks, audiobooks, and videos from thousands of public libraries worldwide. Comprehensive analytical chemistry advances in ion mobility. There has been great progress in the field of imsms since the launch of our first ebook, which has now been downloaded more than 4000 times.
Ion mobility im has been increasingly used in combination with mass spectrometry ms for chemical and biological analysis. Ion mobility mass spectrometry 3 where q is the charge on the ion, n is the number density of the buffer gas, k is the boltzmanns constant, t is the absolute temperature, m is the mass of the buffer gas, m is the mass of the ion, and is the collision crosssection of the ion. Chapter 2 detection of explosives by mass spectrometry. Trapped ion mobility spectrometry tims is a relatively new gasphase separation method that has been coupled to quadrupole orthogonal acceleration timeofflight mass spectrometry.
The analytical power of ion mobility spectrometrymass spectrometry imsms instruments is poised to advance this technology from research to analytical laboratories. Whether youve loved the book or not, if you give your honest and detailed thoughts then people will find new books that are right for them. It has been shown that ion mobility spectrometry mass spectrometry imsms can distinguish isomeric compounds that have identical mz ratios 143. This book focuses on ion mobilitymass spectrometry imms and informatics approaches to improve traditional analysis of molecules by providing. The select series cyclic ims is a revolutionary ion mobility mass spectrometer that combines novel cyclic ion mobility with the latest tof technology, enabling you. There has been great progress in the field of imsms since the launch of. Purchase advances in ion mobilitymass spectrometry. Wilkins, 97814398249, available at book depository with free delivery worldwide. For reproduction of material from all other rsc journals and books. Overview ion mobility spectrometry is a gasphase separation method that is applicable for a wide variety of substances. It describes an ionmobilitycapable quadrupole timeofflight mass spectrometer, the differential mobility analyzer, a cryogenictemperature ion mobility mass spectrometer, the atmospheric solids analysis probe method, and laserspray ionization.
1484 1289 1400 659 1108 1132 638 761 1148 1331 595 172 983 246 1351 201 1427 1417 1518 522 421 1042 948 1374 318 1337 455 1323 351 511 652